Pharmacology Studies
Rigorous Pharmacology for Decision-Ready Preclinical Data
From target engagement profiling to full PK/PD characterisation, our pharmacology services generate the quantitative evidence your regulatory package demands.
Request a study design
A Full-Spectrum Pharmacology Package
Each service can be delivered as a standalone study or integrated into a comprehensive IND-enabling package.
Target Engagement & Binding
Receptor occupancy, binding kinetics and functional target engagement assays across in vitro and ex vivo systems. Selectivity profiling against related family members.
Request protocol →Dose-Response Characterisation
EC50/IC50 determination, Hill slope analysis and full dose-response profiling in relevant pharmacological models. Therapeutic window definition with supporting PK data.
Request protocol →PK/PD Modelling
Integrated pharmacokinetic/pharmacodynamic modelling linking plasma and tissue concentrations to efficacy and safety biomarkers. Non-compartmental and compartmental analyses.
Request protocol →Safety Pharmacology
Core battery studies (CNS, cardiovascular, respiratory) aligned with ICH S7A and S7B guidelines. hERG channel assays, in vivo haemodynamic monitoring and respiratory function.
Request protocol →Drug Combination Studies
Synergy and antagonism assessment using Chou-Talalay and Bliss independence models. Combination index calculations with full statistical reporting for mechanistic interpretation.
Request protocol →Bioanalytical Support
LC-MS/MS quantification of small molecules and biologics in plasma, tissue and CSF. Method development and validation to GLP standards with full chain-of-custody documentation.
Request protocol →Therapeutic Focus Areas
Deep disease-area knowledge informs every aspect of study design — from model choice to the pharmacological read-outs that matter most to regulators and partners.
Oncology
Antitumour pharmacology for small molecules, biologics and cell therapies. Exposure-efficacy relationships, resistance mechanism profiling and combination regimen optimisation.
- Tumour PK and target occupancy
- Biomarker-directed dose selection
- PD endpoint validation
- Combination index modelling
CNS & Neuroscience
CNS penetration studies, receptor occupancy by PET surrogate and behavioural PD end-points for neurological and psychiatric drug candidates.
- Brain-to-plasma ratio determination
- P-gp substrate assessment
- Ex vivo receptor binding
- Microdialysis sampling
Inflammation & Immunology
Mechanistic pharmacology for immunomodulatory compounds — cytokine inhibition profiling, immune cell functional assays and ex vivo whole blood pharmacodynamics.
- Cytokine suppression EC50
- Immune cell proliferation assays
- Whole blood LPS stimulation
- Multiplex cytokine profiling
Pharmacological Read-Outs We Deliver as Standard
All read-outs are pre-specified in the protocol and reported with complete statistical analysis in regulatory-ready format.
Pharmacokinetics
Cmax, AUC, t½, CL, Vd and bioavailability from multi-timepoint sampling. Tissue distribution and CSF penetration on request.
Pharmacodynamics
Target engagement, downstream biomarker modulation and functional read-outs linked directly to the PK profile via PK/PD modelling.
Safety Signals
Clinical observations, body weight, haematology, clinical chemistry and selected organ weights. hERG and in vivo cardiovascular endpoints as needed.
Statistical Analysis
ANOVA, Dunnett’s test, Kaplan-Meier and non-linear regression. All analyses conducted in GraphPad Prism with full methodology documented in the study report.
From Compound Brief to Final Report
A structured three-phase process designed to eliminate ambiguity and keep your programme on schedule.
Study Design & Feasibility
We review your compound profile, therapeutic indication and regulatory context. Our pharmacologists propose the most informative study design with full scientific justification and agreed success criteria.
GLP-Compliant Execution
Dosing, sampling, bioanalysis and pharmacodynamic assessments conducted under continuous quality oversight. Weekly status updates and real-time data access for your team throughout the study.
Analysis, Report & Debrief
PK/PD modelling, full statistical analysis and a regulatory-ready report delivered within agreed timelines, followed by a dedicated scientific debrief session with the study pharmacologist.
Our Pharmacology Track Record
Ready to Characterise Your Compound?
Share your molecule profile and target indication. Our pharmacology team will outline a tailored study design within 48 hours.
Discuss your project